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COVER PICTURE
What ever happened to molecular modelling? In the early eighties there was a large project called Biosim that involved a group of companies developing quality molecular modelling tools for biological systems. The software ran on large and expensive Silicon graphics, Unix workstations and to minimise a guar oligomer of 2-3 residues would probably take you all night. Minimising an oligomer of 6-10 sugars was completely impractical unless you were willing to wait a couple of months for your results. Molecular modelling and hydrocolloids just didn't seem to fit together in any practical form... Maybe its time to reassess that.
The mannobiose oligomer on our front cover was constructed on an ordinary Unix workstation in our CyberColloids laboratory that cost less than a $1000 and minimised in a matter of seconds. It is now possible to run molecular dynamics minimisations on large polysaccharide oligomers at a fraction of the cost it was twenty years ago. If you have an interesting project that might benefit from some molecular modelling then CyberColloids might be able to provide you with a highly cost effective molecular modelling resource.
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